Morgan Compounding specializes in Women's Health Compounding.
Synthetic Estrogen
Synthetic estrogen is not the same chemical structure of estrogen that the patient’s body is born with. Synthetic estrogens don’t fit the body’s receptors in the ideal physiological manner. This leads to unwanted side effects. Studies have shown that Equine estrogens, such as Premarin®, increase metabolism of estrogen into 4-hydroxy estrones. Studies show 4-hydroxy estrone may directly damage DNA and cause mutations. Therefore it is proposed to enhance cancer development. People who have uterine fibroids also may have increased levels of 4-hydroxy estrone.
Medically, natural estrogen means that it is the same chemical structure that the patient is born with. Natural bioidentical estrogen helps protects against endothelial dysfunction by increasing endothelial nitric oxide.
Estradiol Benefits and Functions
- Increases HDL
- Decreases LDL and total cholesterol
- Decreases triglycerides
- Helps maintain bone structure
- Increases serotonin
- Decreases fatigue
- Works as an antioxidant
- Helps maintain memory and cognitive function
- Helps absorption of magnesium, calcium, and zinc.
Estriol Benefits and Functions:
80 times weaker than estradiol so has a lesser stimulatory effect, this is good because estradiol promotes tissue growth.
Considerable evidence exists to show that it protects against breast cancer, Experimentally estriol is being used in breast cancer patients, it does not have the same bone, heart or brain protection of estradiol but still vitally important.
- Helps maintain pregnancy
- Benefits the vaginal lining
- Estriol blocks estrone, (estrone increases cancer risk), by occupying the estrogen receptor sites on the cells of the breasts
- Controls symptoms of menopause, decreases LDL, increases HDL
- Helps reduce pathogenic bacteria
- Helps restore the proper pH of the vagina, which prevents urinary tract infections
- Helps the GI tract maintain a favorable environment for the growth of lactobacilli
Natural Bio-identical Estrogen Benefits on the Brain
- Increases blood flow
- Increases glucose and oxygen to the neurons
- Protects neurons, increases neurotransmitters
- Keeps the blood-brain barrier working, increases sensitivity to nerve growth factor
- Decreases neuronal generation of Alzheimer’s beta amyloid peptides
- Is a natural antioxidant,
- Increases manual speed and dexterity
- Increases availability of acetylcholine
- Boosts by 30% NMDA receptors to maintain strength and durability of synapse connections involved in creating long-term memories
- Decreases ability to be distracted
- Turns on progesterone receptor cells.
Estrogen benefits on the Brain and common comments from patients with low estrogen per Dr. Pamela Smith:
- “I think that I am losing my mind.”
- “I feel like my body is divorcing itself.”
- “I have lost the ability to spell.”
- “I am always losing my keys.”
- “I may be getting Alzheimer’s disease.”
- Study citation: Sarrel, P., et al., “The mortality toll of estrogen avoidance: An analysis of excess deaths among hysterectomized women aged 50-59 years,” Amer Jour Public Health 2013; July 18.
- Another Study: Another study which was a meta-analysis from 27 published studies showed a 28% reduction in mortality in menopausal women under age 60 who used hormone replacement therapy and the participants also had an improved quality of life.
- Study citation: Salpeter, S., et al., “Bayesian meta-analysis of hormone therapy and mortality in younger postmenopausal women,” Amer Jour Med 2009; 22(11):1016-22.
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Optimize your patients’ experiences with dental procedures and recovery by providing medications that cater to their comfort and specific needs.